Functional MRI of disease progression in Parkinson disease and atypical parkinsonian syndromes.

ABSTRACT:

Objective

To explore longitudinal changes in brain activity in patients with Parkinson disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) using task-based functional MRI (fMRI).

Methods

A total of 112 individuals were scanned 1 year apart while performing a unimanual grip force task: 46 PD, 13 MSA, 19 PSP, and 34 healthy controls. The outcome measure was percent signal change in prespecified regions of interest: putamen, primary motor cortex (M1), supplementary motor area (SMA), and superior motor regions of the cerebellum (lobules V-VI).

Results

Patients with PD showed a decline in functional activity over the course of 1 year in the putamen and M1 compared to controls. Changes after 1 year in MSA were exclusively extrastriatal, and

SUBMITTER: Burciu RG 

PROVIDER: S-EPMC4999161 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature