Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis.

ABSTRACT:

Objective

To test the hypothesis that effects of estrogen-containing hormone therapy on cognitive abilities differ between postmenopausal women near to, and further from, menopause.

Methods

In this randomized, double-blind, placebo-controlled trial, healthy women within 6 years of menopause or 10+ years after menopause were randomly assigned to oral 17β-estradiol 1 mg/d or placebo. Women with a uterus received cyclic micronized progesterone vaginal gel or placebo. The primary outcome assessed at 2.5 and 5 years, compared between treatment groups, was change in a standardized composite of neuropsychological test scores assessing verbal episodic memory. Secondary outcomes assessed executive functions and global cognition.

Results

A total of 567 women were included in mo

SUBMITTER: Henderson VW 

PROVIDER: S-EPMC4999165 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature