Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementia.

ABSTRACT:

Objective

To examine neurodegenerative imaging biomarkers in Alzheimer disease (AD) dementia from middle to old age.

Methods

Persons with AD dementia and elevated brain β-amyloid with Pittsburgh compound B (PiB)-PET imaging underwent [(18)F]-fluorodeoxyglucose (FDG)-PET and structural MRI. We evaluated 3 AD-related neurodegeneration biomarkers: hippocampal volume adjusted for total intracranial volume (HVa), FDG standardized uptake value ratio (SUVR) in regions of interest linked to AD, and cortical thickness in AD-related regions of interest. We examined associations of each biomarker with age and evaluated age effects on cutpoints defined by the 90th percentile in AD dementia. We assembled an age-, sex-, and intracranial volume-matched group of 194 similarly imaged clinica

SUBMITTER: Knopman DS 

PROVIDER: S-EPMC4999168 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature