Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression.

ABSTRACT: The adaptive mechanisms of homo- and heterosynaptic plasticity play an important role in learning and memory. In order to maintain plasticity-induced changes for longer time scales (up to several days), they have to be consolidated by transferring them from a short-lasting early-phase to a long-lasting late-phase state. The underlying processes of this synaptic consolidation are already well-known for homosynaptic plasticity, however, it is not clear whether the same processes also enable the induction and consolidation of heterosynaptic plasticity. In this study, by extending a generic calcium-based plasticity model with the processes of synaptic consolidation, we show in simulations that indeed heterosynaptic plasticity can be induced and, furthermore, consolidated by the same underlying

SUBMITTER: Li Y 

PROVIDER: S-EPMC4999190 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature