Exploratory Network Meta Regression Analysis of Stroke Prevention in Atrial Fibrillation Fails to Identify Any Interactions with Treatment Effect.

ABSTRACT:

Background

Patients with atrial fibrillation are at a greater risk of stroke and therefore the main goal for treatment of patients with atrial fibrillation is to prevent stroke from occurring. There are a number of different stroke prevention treatments available to include warfarin and novel oral anticoagulants. Previous network meta-analyses of novel oral anticoagulants for stroke prevention in atrial fibrillation acknowledge the limitation of heterogeneity across the included trials but have not explored the impact of potentially important treatment modifying covariates.

Objectives

To explore potentially important treatment modifying covariates using network meta-regression analyses for stroke prevention in atrial fibrillation.

Methods

We performed a network meta-a

SUBMITTER: Batson S 

PROVIDER: S-EPMC4999289 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature