Collagenase Treatment in Dupuytren Contractures: A Review of the Current State Versus Future Needs.

ABSTRACT: Dupuytren disease is highly prevalent and the finger contractures can be very extensile, compromising the patients' hand function. To restore full function, contractures have been addressed by cutting the causative strands for nearly 200 years, ever since Baron Guillaume Dupuytren demonstrated his technique at the beginning of the nineteenth century. Surgery can be minimal (fasciotomy) or quite invasive (fasciectomy and even skin replacement). However, in the last decade translational research has introduced the non-surgical technique of enzymatic fasciotomy with collagenase injections. Now, finger contractures can be released with single injections on monthly intervals, to address one joint contracture at a time. However, in hands affected with Dupuytren contractures to the extent that th

SUBMITTER: Degreef I 

PROVIDER: S-EPMC4999577 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature