Computational analysis of translational readthrough proteins in Drosophila and yeast reveals parallels to alternative splicing.

ABSTRACT: In translational readthrough (TR) the ribosome continues extending the nascent protein beyond the first in-frame termination codon. Due to the lack of dedicated analyses of eukaryotic TR cases, the associated functional-evolutionary advantages are still unclear. Here, based on a variety of computational methods, we describe the structural and functional properties of previously proposed D. melanogaster and S. cerevisiae TR proteins and extensions. We found that in D. melanogaster TR affects long proteins in mainly regulatory roles. Their TR-extensions are structurally disordered and rich in binding motifs, which, together with their cell-type- and developmental stage-dependent inclusion, suggest that similarly to alternatively spliced exons they rewire cellular interaction networks in a te

SUBMITTER: Pancsa R 

PROVIDER: S-EPMC4999894 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature