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Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata.

ABSTRACT: Two new cubitanoids, nanoculones A and B (1 and 2), and three new cembranoids, nanolobols A-C (3-5), as well as six known compounds, calyculone I (6), sinulariuol A (7), sinulariols C, D, H, and J (8-11), were isolated from the soft coral Sinularia nanolobata, collected off the coast of the eastern region of Taiwan. Their structures were elucidated on the basis of extensive spectroscopic analysis. Cytotoxicity of compounds 1-11 was evaluated. The nitric oxide (NO) inhibitory activity of selected compounds was further measured by assay of lipopolysaccharide (LPS)-stimulated NO production in activated RAW264.7 cells. The results showed that none of 1-11 exhibited cytotoxicity against the tested cancer cell lines, whereas compound 8 was found to significantly reduce NO production.

SUBMITTER: Chao CH

PROVIDER: S-EPMC4999911 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata.

Chao Chih-Hua CH Wu Chia-Yun CY Huang Chiung-Yao CY Wang Hui-Chun HC Dai Chang-Feng CF Wu Yang-Chang YC Sheu Jyh-Horng JH

Marine drugs 20160809 8

Two new cubitanoids, nanoculones A and B (1 and 2), and three new cembranoids, nanolobols A-C (3-5), as well as six known compounds, calyculone I (6), sinulariuol A (7), sinulariols C, D, H, and J (8-11), were isolated from the soft coral Sinularia nanolobata, collected off the coast of the eastern region of Taiwan. Their structures were elucidated on the basis of extensive spectroscopic analysis. Cytotoxicity of compounds 1-11 was evaluated. The nitric oxide (NO) inhibitory activity of selected ...[more]

PMID: 27517938

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