Characterization of Key Helicobacter pylori Regulators Identifies a Role for ArsRS in Biofilm Formation.

ABSTRACT:

Unlabelled

Helicobacter pylori must be able to rapidly respond to fluctuating conditions within the stomach. Despite this need for constant adaptation, H. pylori encodes few regulatory proteins. Of the identified regulators, the ferric uptake regulator (Fur), the nickel response regulator (NikR), and the two-component acid response system (ArsRS) are each paramount to the success of this pathogen. While numerous studies have individually examined these regulatory proteins, little is known about their combined effect. Therefore, we constructed a series of isogenic mutant strains that contained all possible single, double, and triple regulatory mutations in Fur, NikR, and ArsS. A growth curve analysis revealed minor variation in growth kinetics across the strains; these were most pro

SUBMITTER: Servetas SL 

PROVIDER: S-EPMC4999924 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature