Common dysregulated pathways in obese adipose tissue and atherosclerosis.

ABSTRACT:

Background

The metabolic syndrome is becoming increasingly prevalent in the general population that is at simultaneous risk for both type 2 diabetes and cardiovascular disease. The critical pathogenic mechanisms underlying these diseases are obesity-driven insulin resistance and atherosclerosis, respectively. To obtain a better understanding of molecular mechanisms involved in pathogenesis of the metabolic syndrome as a basis for future treatment strategies, studies considering both inherent risks, namely metabolic and cardiovascular, are needed. Hence, the aim of this study was to identify pathways commonly dysregulated in obese adipose tissue and atherosclerotic plaques.

Methods

We carried out a gene set enrichment analysis utilizing data from two microarray experiments wi

SUBMITTER: Moreno-Viedma V 

PROVIDER: S-EPMC5000404 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature