Genetic effects on serum testosterone and sex hormone-binding globulin in men: a Korean twin and family study.

ABSTRACT: We conducted a community-based cross-sectional study to evaluate the role of genetics in determining the individual difference in total testosterone and sex hormone-binding globulin levels. Study participants comprised 730 Korean men consisting of 142 pairs of monozygotic twins, 191 pairs of siblings, and 259 father-offspring pairs from 270 families who participated in the Healthy Twin study. Serum concentration of total testosterone and sex hormone-binding globulin were measured by chemiluminescence immunoassay, and free testosterone and bioavailable testosterone were calculated using Vermeulen's method. Quantitative genetic analysis based on a variance decomposition model showed that the heritability of total testosterone, free testosterone, bioavailable testosterone, and sex hormone-bin

SUBMITTER: Sung J 

PROVIDER: S-EPMC5000805 | biostudies-literature | 2016 Sep-Oct

REPOSITORIES: biostudies-literature