Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study.

ABSTRACT:

Objective

β-Cell autoantibodies are a feature of the preclinical phase of type 1 diabetes. Here, we asked how frequently they revert in a cohort of children at risk for type 1 diabetes and whether reversion has any effect on type 1 diabetes risk.

Research design and methods

Children were up to 10 years of age and screened more than once for insulin autoantibody, GAD antibody, and insulinoma antigen-2 antibodies. Persistent autoantibody was defined as an autoantibody present on two or more consecutive visits and confirmed in two reference laboratories. Reversion was defined as two or more consecutive negative visits after persistence. Time-dependent Cox regression was used to examine how reversion modified the risk of development of multiple autoantibodies and type 1 diabetes

SUBMITTER: Vehik K 

PROVIDER: S-EPMC5001144 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature