Whole blood transcriptional profiling comparison between different milk yield of Chinese Holstein cows using RNA-seq data.

ABSTRACT:

Background

The objective of this research was to investigate the variation of gene expression in the blood transcriptome profile of Chinese Holstein cows associated to the milk yield traits.

Results

We used RNA-seq to generate the bovine transcriptome from the blood of 23 lactating Chinese Holstein cows with extremely high and low milk yield. A total of 100 differentially expressed genes (DEGs) (p < 0.05, FDR < 0.05) were revealed between the high and low groups. Gene ontology (GO) analysis demonstrated that the 100 DEGs were enriched in specific biological processes with regard to defense response, immune response, inflammatory response, icosanoid metabolic process, and fatty acid metabolic process (p < 0.05). The KEGG pathway analysis with 100 DEGs revealed that the most s

SUBMITTER: Bai X 

PROVIDER: S-EPMC5001199 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature