Comprehensive comparison of molecular portraits between cell lines and tumors in breast cancer.

ABSTRACT:

Background

Proper cell models for breast cancer primary tumors have long been the focal point in the cancer's research. The genomic comparison between cell lines and tumors can investigate the similarity and dissimilarity and help to select right cell model to mimic tumor tissues to properly evaluate the drug reaction in vitro. In this paper, a comprehensive comparison in copy number variation (CNV), mutation, mRNA expression and protein expression between 68 breast cancer cell lines and 1375 primary breast tumors is conducted and presented.

Results

Using whole genome expression arrays, strong correlations were observed between cells and tumors. PAM50 gene expression differentiated them into four major breast cancer subtypes: Luminal A and B, HER2amp, and Basal-like in both

SUBMITTER: Jiang G 

PROVIDER: S-EPMC5001206 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature