Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure.

ABSTRACT: Bisphenol-A (BPA) is an environmentally ubiquitous estrogen-like endocrine-disrupting compound. Exposure to BPA in utero has been linked to female reproductive disorders, including endometrial hyperplasia and breast cancer. Estrogens are an etiological factor in many of these conditions. We sought to determine whether in utero exposure to BPA altered the global CpG methylation pattern of the uterine genome, subsequent gene expression, and estrogen response. Pregnant mice were exposed to an environmentally relevant dose of BPA or DMSO control. Uterine DNA and RNA were examined by using methylated DNA immunoprecipitation methylation microarray, expression microarray, and quantitative PCR. In utero BPA exposure altered the global CpG methylation profile of the uterine genome and subsequent ge

SUBMITTER: Jorgensen EM 

PROVIDER: S-EPMC5001514 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature