Ontology highlight
ABSTRACT:
SUBMITTER: Shcherbik N
PROVIDER: S-EPMC5001609 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Shcherbik Natalia N Chernova Tatiana A TA Chernoff Yury O YO Pestov Dimitri G DG
Nucleic acids research 20160620 14
Cotranslational degradation of polypeptide nascent chains plays a critical role in quality control of protein synthesis and the rescue of stalled ribosomes. In eukaryotes, ribosome stalling triggers release of 60S subunits with attached nascent polypeptides, which undergo ubiquitination by the E3 ligase Ltn1 and proteasomal degradation facilitated by the ATPase Cdc48. However, the identity of factors acting upstream in this process is less clear. Here, we examined how the canonical release facto ...[more]