Lower expressed miR-198 and its potential targets in hepatocellular carcinoma: a clinicopathological and in silico study.

ABSTRACT:

Purpose

To investigate the clinicopathological value and potential roles of microRNA-198 (miR-198) in hepatocellular carcinoma (HCC).

Methods

Ninety-five formalin-fixed paraffin-embedded HCC and the para-cancerous liver tissues were gathered. Real-time reverse transcription quantitative polymerase chain reaction was applied to determine the miR-198 expression. The association between the miR-198 expression and clinicopathological features was examined. Meanwhile, potential target messenger RNAs of miR-198 in HCC were obtained from 14 miRNA prediction databases and natural language processing method, in which we pooled the genes related to the tumorigenesis and progression of HCC and classified them by their frequency. The selected target genes were finally analyzed in the Ge

SUBMITTER: Huang WT 

PROVIDER: S-EPMC5001667 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature