Spatio-Temporal Distribution of Mycobacterium tuberculosis Complex Strains in Ghana.

ABSTRACT:

Background

There is a perception that genomic differences in the species/lineages of the nine species making the Mycobacterium tuberculosis complex (MTBC) may affect the efficacy of distinct control tools in certain geographical areas. We therefore analyzed the prevalence and spatial distribution of MTBC species and lineages among isolates from pulmonary TB cases over an 8-year period, 2007-2014.

Methodology

Mycobacterial species isolated by culture from consecutively recruited pulmonary tuberculosis patients presenting at selected district/sub-district health facilities were confirmed as MTBC by IS6110 and rpoß PCR and further assigned lineages and sub lineages by spoligotyping and large sequence polymorphism PCR (RDs 4, 9, 12, 702, 711) assays. Patient characteristics, res

SUBMITTER: Yeboah-Manu D 

PROVIDER: S-EPMC5001706 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature