Efficient Reconstruction of Predictive Consensus Metabolic Network Models.

ABSTRACT: Understanding cellular function requires accurate, comprehensive representations of metabolism. Genome-scale, constraint-based metabolic models (GSMs) provide such representations, but their usability is often hampered by inconsistencies at various levels, in particular for concurrent models. COMMGEN, our tool for COnsensus Metabolic Model GENeration, automatically identifies inconsistencies between concurrent models and semi-automatically resolves them, thereby contributing to consolidate knowledge of metabolic function. Tests of COMMGEN for four organisms showed that automatically generated consensus models were predictive and that they substantially increased coherence of knowledge representation. COMMGEN ought to be particularly useful for complex scenarios in which manual curation doe

SUBMITTER: van Heck RG 

PROVIDER: S-EPMC5001716 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature