Material-driven fibronectin assembly for high-efficiency presentation of growth factors.

ABSTRACT: Growth factors (GFs) are powerful signaling molecules with the potential to drive regenerative strategies, including bone repair and vascularization. However, GFs are typically delivered in soluble format at supraphysiological doses because of rapid clearance and limited therapeutic impact. These high doses have serious side effects and are expensive. Although it is well established that GF interactions with extracellular matrix proteins such as fibronectin control GF presentation and activity, a translation-ready approach to unlocking GF potential has not been realized. We demonstrate a simple, robust, and controlled material-based approach to enhance the activity of GFs during tissue healing. The underlying mechanism is based on spontaneous fibrillar organization of fibronectin driven by

SUBMITTER: Llopis-Hernandez V 

PROVIDER: S-EPMC5001810 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature