Inflammation and neuroprotection in traumatic brain injury.

ABSTRACT:

Importance

Traumatic brain injury (TBI) is a significant public health concern that affects individuals in all demographics. With increasing interest in the medical and public communities, understanding the inflammatory mechanisms that drive the pathologic and consequent cognitive outcomes can inform future research and clinical decisions for patients with TBI.

Objectives

To review known inflammatory mechanisms in TBI and to highlight clinical trials and neuroprotective therapeutic manipulations of pathologic and inflammatory mechanisms of TBI.

Evidence review

We searched articles in PubMed published between 1960 and August 1, 2014, using the following keywords: traumatic brain injury, sterile injury, inflammation, astrocytes, microglia, monocytes, macrophages, neutro

SUBMITTER: Corps KN 

PROVIDER: S-EPMC5001842 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature