The Effects of Gonadotropin-Releasing Hormone Agonist Combined with Add-Back Therapy on Quality of Life for Adolescents with Endometriosis: A Randomized Controlled Trial.

ABSTRACT:

Study objective

Use of gonadotropin-releasing hormone agonists (GnRHa) to treat endometriosis can cause mood and vasomotor side effects. "Add-back therapy," the combination of low-dose hormones, limits side effects but research is limited to adults. We sought to characterize quality of life (QOL) before treatment and to compare an add-back regimen of norethindrone acetate (NA) with conjugated estrogens (CEE) to NA alone for preventing side effects of GnRHa therapy in female adolescents with endometriosis.

Design

Twelve-month double-blind, placebo-controlled trial.

Setting

Pediatric Gynecology clinic in Boston, Massachusetts.

Participants

Fifty female adolescents (aged 15-22 years) with surgically confirmed endometriosis initiating treatment with GnRHa.

Inter

SUBMITTER: Sadler Gallagher J 

PROVIDER: S-EPMC5001926 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature