G23D: Online tool for mapping and visualization of genomic variants on 3D protein structures.

ABSTRACT:

Background

Evaluation of the possible implications of genomic variants is an increasingly important task in the current high throughput sequencing era. Structural information however is still not routinely exploited during this evaluation process. The main reasons can be attributed to the partial structural coverage of the human proteome and the lack of tools which conveniently convert genomic positions, which are the frequent output of genomic pipelines, to proteins and structure coordinates.

Results

We present G23D, a tool for conversion of human genomic coordinates to protein coordinates and protein structures. G23D allows mapping of genomic positions/variants on evolutionary related (and not only identical) protein three dimensional (3D) structures as well as on theoreti

SUBMITTER: Solomon O 

PROVIDER: S-EPMC5002099 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature