Long-term follow-up of HIV seroconverters in microbicide trials - rationale, study design, and challenges in MTN-015.

ABSTRACT:

Background

As the effect of biomedical prevention interventions on the natural history of HIV-1 infection in participants who seroconvert is unknown, the Microbicide Trials Network (MTN) established a longitudinal study (MTN-015) to monitor virologic, immunological, and clinical outcomes, as well as behavioral changes among women who become HIV-infected during MTN trials. We describe the rationale, study design, implementation, and enrollment of the initial group of participants in the MTN seroconverter cohort.

Methods

Initiated in 2008, MTN-015 is an ongoing observational cohort study enrolling participants who acquire HIV-1 infection during effectiveness studies of candidate microbicides. Eligible participants from recently completed and ongoing MTN trials are enrolled aft

SUBMITTER: Riddler SA 

PROVIDER: S-EPMC5002236 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature