Toll-like Receptor function of murine macrophages, probed by cytokine induction, is biphasic and is not impaired globally with age.

ABSTRACT: Aging is associated with a waning of normal immune function. This "immunosenescence" is characterized by a diverse repertoire of seemingly discreet and unbalanced immune alterations. A number of studies have suggested that aging-associated alterations in innate immune responsiveness, especially responsiveness dependent on Toll-like Receptor (TLR) engagement, are causally involved. We find, however, that the magnitude and dose-dependency of responsiveness to TLR engagement (assessed with respect to cytokine production) in distinct populations of murine macrophages are not altered generally with animal age or as a consequence of immunosenescence. Responses elicited with a wide array of TLR agonists were examined by extensive functional analyses, principally on the level of the individual cel

SUBMITTER: Pattabiraman G 

PROVIDER: S-EPMC5002374 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature