A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score.

ABSTRACT:

Background

Despite revisions in 2005 and 2014, the Gleason prostate cancer (PCa) grading system still has major deficiencies. Combining of Gleason scores into a three-tiered grouping (6, 7, 8-10) is used most frequently for prognostic and therapeutic purposes. The lowest score, assigned 6, may be misunderstood as a cancer in the middle of the grading scale, and 3+4=7 and 4+3=7 are often considered the same prognostic group.

Objective

To verify that a new grading system accurately produces a smaller number of grades with the most significant prognostic differences, using multi-institutional and multimodal therapy data.

Design, setting, and participants

Between 2005 and 2014, 20,845 consecutive men were treated by radical prostatectomy at five academic institutions; 550

SUBMITTER: Epstein JI 

PROVIDER: S-EPMC5002992 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature