Attenuated anticorrelation between the default and dorsal attention networks with aging: evidence from task and rest.

ABSTRACT: Anticorrelation between the default and dorsal attention networks is a central feature of human functional brain organization. Hallmarks of aging include impaired default network modulation and declining medial temporal lobe (MTL) function. However, it remains unclear if this anticorrelation is preserved into older adulthood during task performance, or how this is related to the intrinsic architecture of the brain. We hypothesized that older adults would show reduced within- and increased between-network functional connectivity (FC) across the default and dorsal attention networks. To test this hypothesis, we examined the effects of aging on task-related and intrinsic FC using functional magnetic resonance imaging during an autobiographical planning task known to engage the default network

SUBMITTER: Spreng RN 

PROVIDER: S-EPMC5003045 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature