Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Rationale

The small conducting airways are the major site of airflow obstruction in chronic obstructive pulmonary disease and may precede emphysema development.

Objectives

We hypothesized a novel computed tomography (CT) biomarker of small airway disease predicts FEV1 decline.

Methods

We analyzed 1,508 current and former smokers from COPDGene with linear regression to assess predictors of change in FEV1 (ml/yr) over 5 years. Separate models for subjects without and with airflow obstruction were generated using baseline clinical and physiologic predictors in addition to two novel CT metrics created by parametric response mapping (PRM), a technique pairing inspiratory and expiratory CT images to define emphysema (PRM(emph)) and functional small airways disease (PRM(fSAD

SUBMITTER: Bhatt SP 

PROVIDER: S-EPMC5003216 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature