Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models.

ABSTRACT:

Background & aims

Hepatic fibrosis, featured by the accumulation of excessive extracellular matrix in liver tissue, is associated with metabolic disease and cancer. Inhalation exposure to airborne particulate matter in fine ranges (PM2.5) correlates with pulmonary dysfunction, cardiovascular disease, and metabolic syndrome. In this study, we investigated the effect and mechanism of PM2.5 exposure on hepatic fibrogenesis.

Methods

Both inhalation exposure of mice and in vitro exposure of specialized cells to PM2.5 were performed to elucidate the effect of PM2.5 exposure on hepatic fibrosis. Histological examinations, gene expression analyses, and genetic animal models were utilized to determine the effect and mechanism by which PM2.5 exposure promotes hepatic fibrosis.

Resu

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC5003300 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature