Identifying Potential Regions of Copy Number Variation for Bipolar Disorder.

ABSTRACT: Bipolar disorder is a complex psychiatric disorder with high heritability, but its genetic determinants are still largely unknown. Copy number variation (CNV) is one of the sources to explain part of the heritability. However, it is a challenge to estimate discrete values of the copy numbers using continuous signals calling from a set of markers, and to simultaneously perform association testing between CNVs and phenotypic outcomes. The goal of the present study is to perform a series of data filtering and analysis procedures using a DNA pooling strategy to identify potential CNV regions that are related to bipolar disorder. A total of 200 normal controls and 200 clinically diagnosed bipolar patients were recruited in this study, and were randomly divided into eight control and eight case

SUBMITTER: Chen YH 

PROVIDER: S-EPMC5003455 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature