Comparative Analyses of MicroRNA Microarrays during Cardiogenesis: Functional Perspectives.

ABSTRACT: Cardiovascular development is a complex process in which several transcriptional pathways are operative, providing instructions to the developing cardiomyocytes, while coping with contraction and morphogenetic movements to shape the mature heart. The discovery of microRNAs has added a new layer of complexity to the molecular mechanisms governing the formation of the heart. Discrete genetic ablation of the microRNAs processing enzymes, such as Dicer and Drosha, has highlighted the functional roles of microRNAs during heart development. Importantly, selective deletion of a single microRNA, miR-1-2, results in an embryonic lethal phenotype in which both morphogenetic, as well as impaired conduction, phenotypes can be observed. In an effort to grasp the variability of microRNA expression durin

SUBMITTER: Bonet F 

PROVIDER: S-EPMC5003481 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature