Stromal Activation by Tumor Cells: An in Vitro Study in Breast Cancer.

ABSTRACT:

Background

The tumor microenvironment participates in the regulation of tumor progression and influences treatment sensitivity. In breast cancer, it also may play a role in determining the fate of non-invasive lesions such as ductal carcinoma in situ (DCIS), a non-obligate precursor of invasive diseases, which is aggressively treated despite its indolent nature in many patients since no biomarkers are available to predict the progression of DCIS to invasive disease. In vitro models of stromal activation by breast tumor cells might provide clues as to specific stromal genes crucial for the transition from DCIS to invasive disease.

Methods

normal human dermal fibroblasts (NHDF) were treated under serum-free conditions with cell culture media conditioned by breast cancer cell l

SUBMITTER: Merlino G 

PROVIDER: S-EPMC5003486 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature