Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats.

ABSTRACT:

Rationale

The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models.

Objectives

The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)-seeking in rats pre-exposed to a predator odor threat.

Methods

In Experiment 1, rats were exposed for 5 days to the predator odor, 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), or saline before METH self-administration began. After extinction training, rats were injected with 1 mg/kg, ip oxytocin (OXT) or saline 30 min before a cue-induced reinstatement test followed by re-extinction and a TMT-induced reinstatement test. In Experiment 2, TMT pre-exposure was followed by 10 days of 1 mg/kg OXT or saline injections before METH self-

SUBMITTER: Ferland CL 

PROVIDER: S-EPMC5003622 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature