Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors.

ABSTRACT:

Purpose/objectives

Radiation injury to parahippocampal cingulum white matter is associated with cognitive decline. Diffusion tensor imaging (DTI) detects micropathologic changes in white matter. Increased radial diffusion (RD) and decreased axial diffusion (AD) correspond to demyelination and axonal degeneration/gliosis respectively. We aimed to develop a predictive model for radiation-induced cognitive changes based upon DTI changes.

Materials/methods

Twenty-seven adults with benign or low-grade tumors received partial brain radiation therapy (RT) to a median dose of 54Gy. Patients underwent DTI before RT, during RT, and at the end of RT. Cognitive testing was performed before RT, and 6 and 18months after RT. Parahippocampal cingulum white matter was contoured to obtain mea

SUBMITTER: Chapman CH 

PROVIDER: S-EPMC5003665 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature