Ontology highlight
ABSTRACT:
SUBMITTER: da Cruz EHG
PROVIDER: S-EPMC5003678 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20160614
Selenium-containing quinone-based 1,2,3-triazoles were synthesized using click chemistry, the copper catalyzed azide-alkyne 1,3-dipolar cycloaddition, and evaluated against six types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), PC3 (human prostate cells), SF295 (human glioblastoma cells), MDA-MB-435 (melanoma cells) and OVCAR-8 (human ovarian carcinoma cells). Some compounds showed IC50 values < 0.3 μM. The cytotoxic potential of the qu ...[more]