Fast and slow transitions in frontal ensemble activity during flexible sensorimotor behavior.

ABSTRACT: The ability to shift between repetitive and goal-directed actions is a hallmark of cognitive control. Previous studies have reported that adaptive shifts in behavior are accompanied by changes of neural activity in frontal cortex. However, neural and behavioral adaptations can occur at multiple time scales, and their relationship remains poorly defined. Here we developed an adaptive sensorimotor decision-making task for head-fixed mice, requiring them to shift flexibly between multiple auditory-motor mappings. Two-photon calcium imaging of secondary motor cortex (M2) revealed different ensemble activity states for each mapping. When adapting to a conditional mapping, transitions in ensemble activity were abrupt and occurred before the recovery of behavioral performance. By contrast, gradua

SUBMITTER: Siniscalchi MJ 

PROVIDER: S-EPMC5003707 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature