Genetic Modifiers of Patent Ductus Arteriosus in Term Infants.

ABSTRACT:

Objective

To identify single-nucleotide polymorphisms (SNPs) in specific candidate genes associated with patent ductus arteriosus in term infants.

Study design

We conducted an initial family-based, candidate gene study to analyze genotype data from DNA samples obtained from 171 term infants and their parents enrolled in the National Birth Defects Prevention Study (NBDPS). We performed transmission disequilibrium testing (TDT) using a panel of 55 SNPs in 17 genes. Replication of SNPs with P < .1 in the NBDPS trios was performed with a case-control strategy in an independent population.

Results

TDT analysis of the NBDPS trios resulted in 6 SNPs reaching the predetermined cutoff (P < .1) to be included in the replication study. These 6 SNPs were genotyped in the independ

SUBMITTER: Patel PM 

PROVIDER: S-EPMC5003735 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature