Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol.

ABSTRACT: Few effective therapies exist for the treatment of neurodegenerative diseases that have been characterized as protein misfolding disorders. Upregulation of heat shock proteins (Hsps) mitigates against the accumulation of misfolded, aggregation-prone proteins and synaptic dysfunction, which is recognized as an early event in neurodegenerative diseases. Enhanced induction of a set of Hsps in differentiated human SH-SY5Y neuronal cells was observed following co-application of celastrol and arimoclomol, compared to their individual application. The dosages employed did not affect cell viability or neuronal process morphology. The induced Hsps included the little studied HSPA6 (Hsp70B'), a potentially neuroprotective protein that is present in the human genome but not in rat and mouse and hence

SUBMITTER: Deane CA 

PROVIDER: S-EPMC5003800 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature