Analysis of Network Topologies Underlying Ethylene Growth Response Kinetics.

ABSTRACT: Most models for ethylene signaling involve a linear pathway. However, measurements of seedling growth kinetics when ethylene is applied and removed have resulted in more complex network models that include coherent feedforward, negative feedback, and positive feedback motifs. The dynamical responses of the proposed networks have not been explored in a quantitative manner. Here, we explore (i) whether any of the proposed models are capable of producing growth-response behaviors consistent with experimental observations and (ii) what mechanistic roles various parts of the network topologies play in ethylene signaling. To address this, we used computational methods to explore two general network topologies: The first contains a coherent feedforward loop that inhibits growth and a negative fee

SUBMITTER: Prescott AM 

PROVIDER: S-EPMC5003821 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature