BOLD and its connection to dopamine release in human striatum: a cross-cohort comparison.

ABSTRACT: Activity in midbrain dopamine neurons modulates the release of dopamine in terminal structures including the striatum, and controls reward-dependent valuation and choice. This fluctuating release of dopamine is thought to encode reward prediction error (RPE) signals and other value-related information crucial to decision-making, and such models have been used to track prediction error signals in the striatum as encoded by BOLD signals. However, until recently there have been no comparisons of BOLD responses and dopamine responses except for one clear correlation of these two signals in rodents. No such comparisons have been made in humans. Here, we report on the connection between the RPE-related BOLD signal recorded in one group of subjects carrying out an investment task, and the corresp

SUBMITTER: Lohrenz T 

PROVIDER: S-EPMC5003854 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature