Bidirectional Expression of Metabolic, Structural, and Immune Pathways in Early Myopia and Hyperopia.

ABSTRACT: Myopia (short-sightedness) affects 1.45 billion people worldwide, many of whom will develop sight-threatening secondary disorders. Myopic eyes are characterized by excessive size while hyperopic (long-sighted) eyes are typically small. The biological and genetic mechanisms underpinning the retina's local control of these growth patterns remain unclear. In the present study, we used RNA sequencing to examine gene expression in the retina/RPE/choroid across 3 days of optically-induced myopia and hyperopia induction in chick. Data were analyzed for differential expression of single genes, and Gene Set Enrichment Analysis (GSEA) was used to identify gene sets correlated with ocular axial length and refraction across lens groups. Like previous studies, we found few single genes that were differ

SUBMITTER: Riddell N 

PROVIDER: S-EPMC5003873 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature