Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment.

ABSTRACT: In eukaryotes, genes are frequently interrupted with noncoding sequences named introns. Alternative splicing is a nuclear mechanism by which these introns are removed and flanking coding regions named exons are joined together to generate a message that will be translated in the cytoplasm. This mechanism is catalyzed by a complex machinery known as the spliceosome, which is conformed by more than 300 proteins and ribonucleoproteins that activate and regulate the precision of gene expression when assembled. It has been proposed that several genetic diseases are related to defects in the splicing process, including cancer. For this reason, natural products that show the ability to regulate splicing have attracted enormous attention due to its potential use for cancer treatment. Some microbia

SUBMITTER: Martinez-Montiel N 

PROVIDER: S-EPMC5004037 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature