Fear of Pain Mediates the Association between MC1R Genotype and Dental Fear.

ABSTRACT: Fear of pain is experienced in acute and chronic pain populations, as well as in the general population, and it affects numerous aspects of the orofacial pain experience, including pain intensity, pain-related disability, and pain behavior (e.g., avoidance). A related but separate construct-dental fear-is also experienced in the general population, and it influences dental treatment-seeking behavior and oral and systemic health. Minimal work has addressed the role of genetics in the etiologies of fear of pain and dental fear. Limited available data suggest that variants of the melanocortin 1 receptor (MC1R) gene may predict greater levels of dental fear. The MC1R gene also may be etiologically important for fear of pain. This study aimed to replicate the finding that MC1R variant status pr

SUBMITTER: Randall CL 

PROVIDER: S-EPMC5004243 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature