Individual strains of Lactobacillus paracasei differentially inhibit human basophil and mouse mast cell activation.

ABSTRACT:

Introduction

The microbiota controls a variety of biological functions, including immunity, and alterations of the microbiota in early life are associated with a higher risk of developing allergies later in life. Several probiotic bacteria, and particularly lactic acid bacteria, were described to reduce both the induction of allergic responses and allergic manifestations. Although specific probiotic strains were used in these studies, their protective effects on allergic responses also might be common for all lactobacilli.

Methods

To determine whether allergic effector cells inhibition is a common feature of lactobacilli or whether it varies among lactobacilli strains, we compared the ability of 40 strains of the same Lactobacillus paracasei species to inhibit IgE-dependent

SUBMITTER: Cassard L 

PROVIDER: S-EPMC5004284 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature