Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice.

ABSTRACT:

Introduction

Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.

Methods

To explore the importance of cholesterol homeostasis for asthma, we investigated the contribution of LXR activity in an ovalbumin- and a house dust mite-driven eosinophilic asthma mouse model.

Results

In both models, airway inflammation, airway hyper-reactivity, and goblet cell hyperplasia were reduced in mice deficient for both LXRα and LXRβ isoforms (LXRα(-/-)β(-/-)) as compared to wild-type mice. Inversely, treatment with the LXR agonist GW3965 showed increased eosinophilic airway inflammation. LXR activity c

SUBMITTER: Smet M 

PROVIDER: S-EPMC5004289 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature