IFN-λ3 polymorphism indirectly influences NK cell phenotype and function during acute HCV infection.

ABSTRACT:

Introduction

Polymorphisms in the type III interferon IFN-λ3 and the killer cell immunoglobulin-like receptor (KIR) genes controlling the activity of natural killer (NK) cells can predict spontaneous resolution of acute hepatitis C virus (HCV) infection. We hypothesized that IFN-λ3 polymorphism may modulate NK cell function during acute HCV.

Methods

We monitored the plasma levels of type III IFNs in relation to the phenotype and the function of NK cells in a cohort of people who inject drugs (PWID) during acute HCV infection with different outcomes.

Results

Early acute HCV was associated with high variability in type III IFNs plasma levels and the favorable IFN-λ3 CC genotype was associated with higher viral loads. Reduced expression of Natural Killer Group Protein 2A

SUBMITTER: Depla M 

PROVIDER: S-EPMC5004291 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature