Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.

ABSTRACT:

Background

Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines in TBEV-mediated neurological disease are poorly understood.

Methods

BALB/c mice were intracerebrally injected with TBEV, followed by evaluation of chemokine and cytokine profiles using protein array analysis. The virus-infected mice were treated with the CC chemokine antagonist Met-RANTES or anti-RANTES mAb to determine the role of RANTES in affecting TBEV-induced neurological disease. The underlying signaling mechanisms were delineated using RANTES promoter

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5004318 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature