Pharmacogenetics and interstitial lung disease.

ABSTRACT:

Purpose of review

Interstitial lung disease (ILD) is comprised of a heterogeneous group of disorders with highly variable natural histories and response to therapies. Pharmacogenetics focuses on the variability in drug response because of the presence of genetic factors that influence drug metabolism or disease activity. In this article, we review relevant drug-specific and disease-specific polymorphisms that may influence therapeutic response, and then highlight a recently identified drug-gene interaction in patients with idiopathic pulmonary fibrosis (IPF).

Recent findings

The emergence of high-throughput genomic technology has allowed for identification of gene polymorphisms associated with susceptibility to specific disease states, including IPF and several connective ti

SUBMITTER: Oldham JM 

PROVIDER: S-EPMC5004343 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature