Ultrasensitive Negative Feedback Control: A Natural Approach for the Design of Synthetic Controllers.

ABSTRACT: Many of the most important potential applications of Synthetic Biology will require the ability to design and implement high performance feedback control systems that can accurately regulate the dynamics of multiple molecular species within the cell. Here, we argue that the use of design strategies based on combining ultrasensitive response dynamics with negative feedback represents a natural approach to this problem that fully exploits the strongly nonlinear nature of cellular information processing. We propose that such feedback mechanisms can explain the adaptive responses observed in one of the most widely studied biomolecular feedback systems-the yeast osmoregulatory response network. Based on our analysis of such system, we identify strong links with a well-known branch of mathematic

SUBMITTER: Montefusco F 

PROVIDER: S-EPMC5004582 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature