Combinatory annotation of cell membrane receptors and signalling pathways of Bombyx mori prothoracic glands.

ABSTRACT: The cells of prothoracic glands (PG) are the main site of synthesis and secretion of ecdysteroids, the biochemical products of cholesterol conversion to steroids that shape the morphogenic development of insects. Despite the availability of genome sequences from several insect species and the extensive knowledge of certain signalling pathways that underpin ecdysteroidogenesis, the spectrum of signalling molecules and ecdysteroidogenic cascades is still not fully comprehensive. To fill this gap and obtain the complete list of cell membrane receptors expressed in PG cells, we used combinatory bioinformatic, proteomic and transcriptomic analysis and quantitative PCR to annotate and determine the expression profiles of genes identified as putative cell membrane receptors of the model insect sp

SUBMITTER: Moulos P 

PROVIDER: S-EPMC5004587 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature